Products That Interfere With Zithromax

More Information on Drug Interactions With Zithromax

The following sections explain in detail how the drugs mentioned above can cause potentially negative interactions when combined with Zithromax.
 
QT-Prolonging Medications
Rarely, Zithromax can cause a change in the heart rhythm known as QT prolongation. For many individuals, this is minor and inconsequential. However, in some cases it can lead to a fatal arrhythmia. People who already have a long QT interval (due to genetics, heart problems, electrolyte imbalances, or other medications) are at highest risk for serious problems related to QT prolongation with Zithromax.
  
Warfarin (Coumadin, Jantoven)
If you are taking Zithromax and warfarin, your body may metabolize warfarin differently than intended, perhaps increasing the risk of bleeding. Your healthcare provider may choose to monitor your international normalized ratio (INR) and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
 
Aluminum or Magnesium Antacids
If you are taking both Zithromax and antacids made with aluminum or magnesium, Zithromax may not be absorbed into your body as well as intended. Be sure to take the antacids at least two hours before or two hours after taking Zithromax.
 
Digoxin (Digitek, Lanoxicaps, Lanoxin)
If you combine Zithromax with digoxin, your body may metabolize digoxin differently than intended, perhaps increasing the risk of digoxin toxicity. Discuss this with your healthcare provider prior to starting Zithromax.
 
Tacrolimus (Prograf, Protopic)
If you are taking Zithromax and tacrolimus together, your body may metabolize tacrolimus differently than intended and significantly increase the level of the drug in your system. Your healthcare provider may choose to monitor your progress and adjust your dose accordingly.
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